Transcriptome signature of heart defects.

Comparison of ratios for DE genes up- or down-regulated in the AVSD or ASD+VSD group between (1) array ratio in the Ts21 CHD− vs 2N, (2) array ratio in CHD+ vs CHD−, (3) q-PCR ratio from different experiments in CHD+ vs CHD− using additional samples (total number in parentheses). Gene nomenclature, AUTS2: autism susceptibility candidate 2; CNN2: calponin 2; DSCR3: Down syndrome critical region gene 3; DYNLT3: dynein, light chain, Tctex-type 3; NQO1: NAD(P)H dehydrogenase, quinone 1; OFD1: oral-facial-digital syndrome 1; PDIA4: protein disulfide isomerase family A, member 4; PIGP: phosphatidylinositol glycan anchor biosynthesis, class P; TTC3: tetratricopeptide repeat domain 3; TUBB2B: tubulin, beta 2B; ACTG1: actin, gamma 1; ALDOC: aldolase C, fructose-bisphosphate; CACYBP: calcyclin binding protein; DTYMK: deoxythymidylate kinase (thymidylate kinase); ENO2: enolase 2 (gamma, neuronal); GART: phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; IFNAR1: interferon (alpha, beta, and omega) receptor 1; PLTP: phospholipid transfer protein; RPL10A: ribosomal protein L10a; TNFAIP2: tumor necrosis factor, alpha-induced protein 2.