Bacterial Spore Detection by [Tb3+(macrocycle)(dipicolinate)] Luminescence

Dipicolinic acid (DPA) is a unique constituent of bacterial spores, a dormant form of Bacillus and Clostridium, which can be detected using DPA-triggered Tb3+ luminescence. [Tb(DO2A)]+ improves the sensitivity of bacterial spore detection over Tb3+(aq) owing to the exclusion of coordinated water molecules and represents the first step toward construction of a DPA receptor site with enhanced binding selectivity. The title ternary [Tb(DO2A)(DPA)]- complex was structurally characterized and features two DO2A-DPA interligand hydrogen interactions that stabilize the complex.

二羟基戊二酸（DPA）是细菌芽孢的独特成分，芽孢是枯草杆菌和梭状芽孢杆菌的一种休眠形态，可通过DPA触发的Tb3+发光进行检测。[Tb(DO2A)]+ 通过排除配位水分子，提高了对细菌芽孢检测的灵敏度，这代表着构建具有增强结合选择性的DPA受体位点的第一步。标题中的三元复合物[Tb(DO2A)(DPA)]-的结构已被表征，并具有两个DO2A-DPA桥连氢键相互作用，这些相互作用稳定了该复合物。