Prospective in-silico trials identify combined SK and K2P channel block as an effective strategy for atrial fibrillation cardioversion

This dataset includes the meshes of ten atrial anatomies (AA) ready for simulation using MonoAlg3D (https://github.com/rsachetto/MonoAlg3D_C). Ten folders are provided with the name AtrialAnatomyXX (XX being an integer from 1 to 10). Inside each folder there is 

Geometry with atrial region tags: atria_AA_XX.alg  

Fibers for the corresponding anatomy: atria_AA_XX.fibers 

These atrial anatomies might be presented with absence of low voltage areas (FB_0) or with 15% low voltage areas in the right and left atrium (FB_1). Therefore, the actual names that can be found inside the Baseline folder are: 

atria_AA_XX_FB_0.alg 

atria_AA_XX_FB_1.alg 

atria_AA_XX_FB_0.fibers 

atria_AA_XX_FB_1.fibers 

Inside the Baseline folder there is an additional file with the suffix (*SV_AF.txt). This file includes the State Variables (or initial conditions) needed to impose AF in the tissue for each geometry: 

atria_AA_XX_SV_AF.txt 

Additional to the atrial anatomies, configuration files for running simulations are provided in the folder Configuration_Files.  

There are two sub-folders, one to save the state at 2 seconds of tjhe simulation (only control conditions), another to restore the state and run simulations from 2 until 7 seconds (control and treatment simulations). 

Each configuration file corresponds to a different virtual patient (VirtPat) and has the following name: 

VirtPat_EP_N_AA_XX_FB_YY_TRTM_ZZ.ini 

EP_N (electrophysiology): N is an integer ranging from 1 to 50. Different electrophysiology is reflected in the different scaling factors used for the maximal conductance of ionic currents. 

AA_XX (Atrial anatomy). XX is an integer ranging from 1 to 10. Call to the atrial meshes described above.

FB_YY (Fibrosis). YY is a boolean value, either 0 (no LVA) or 1 (15% LVA).

TRTM_ZZ (Treatment): This is a string that needs to be replaced by the treatment names (e.g., SK_block)