CRYSTAL STRUCTURE OF PI3K DELTA IN COMPLEX WITH A TRIFLUORO-ETHYL-PYRAZOL-PYROLOTRIAZINE INHIBITOR

Protein Data Bank Japan2024-03-13 更新2026-03-21 收录

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CRYSTAL STRUCTURE OF PI3K DELTA IN COMPLEX WITH A TRIFLUORO-ETHYL-PYRAZOL-PYROLOTRIAZINE INHIBITOR Descriptor: 4-acetyl-1-(3-{4-amino-5-[1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}phenyl)-3,3-dimethylpiperazin-2-one, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Authors: Sack, J.S. Deposit date: 2017-04-26 Release date: 2017-06-07 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase delta (PI3K delta ) Inhibitor for the Treatment of Immunological Disorders. J. Med. Chem., 60, 2017

磷脂酰肌醇3-激酶δ（PI3K delta）与三氟乙基吡唑-吡咯并三嗪类抑制剂的复合物晶体结构描述项：4-乙酰基-1-(3-{4-氨基-5-[1-(2,2,2-三氟乙基)-1H-吡唑-5-基]吡咯并[2,1-f][1,2,4]三嗪-7-基}苯基)-3,3-二甲基哌嗪-2-酮、磷脂酰肌醇3-激酶调节亚基α、磷脂酰肌醇4,5-二磷酸3-激酶催化亚基δ亚型作者：Sack, J.S. 提交日期：2017-04-26 发布日期：2017-06-07 最后修改日期：2024-03-13 检测方法：X射线衍射（分辨率2.8埃）引用文献：《用于治疗免疫性疾病的强效、高选择性且疗效优异的磷脂酰肌醇3-激酶δ（PI3Kδ）抑制剂》，《药物化学杂志》，60卷，2017年

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2017-04-26