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High-throughput determination of the antigen specificities of T cell receptors in single cells

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NIAID Data Ecosystem2026-05-26 收录
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High-throughput linking of T cell receptor (TCR) sequences to their binding antigens is vital for immune profiling, yet challenging. We present Tetramer associated TCR Sequencing (TetTCR-Seq) to address this challenge. Binding is determined using a library of DNA-barcoded antigen tetramers that are rapidly and inexpensively generated using an in vitro transcription/translation platform.

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2018-11-23
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