Rhenium and Technetium Complexes with Pentadentate Thiocarbamoylbenzamidines: Steps toward Bioconjugation
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https://figshare.com/articles/dataset/Rhenium_and_Technetium_Complexes_with_Pentadentate_Thiocarbamoylbenzamidines_Steps_toward_Bioconjugation/2158474
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资源简介：
Thiocarbamoylbenzimidoyl chlorides,
PhC(Cl)N–(CS)–NR1R2, react with 2-(iminodiacetic acid)benzylamine under formation of
the potentially pentadentate ligands H3L (R1, R2 = Et) and H3L–COOEt (R1 = Me, R2 = C6H4-4-COOEt) in high
yields. Hydrolysis of H3L–COOEt in NaOH/MeOH gives
quantitatively another benzamidine ligand H3L–COOH.
The novel ligands readily react with (NBu4)[MOCl4] (M = Re, Tc) under formation of stable complexes with the general
composition [MO(L)], in which they are triply deprotonated and fully
occupy the remaining five coordination positions of the {MO}3+ cores. In a “proof-of-principle” reaction for possible
bioconjugations, the complex [ReO(L–COOH)] has been labeled
with triglycine ethyl ester in high yields.
创建时间：
2016-02-13
