Transcriptome profiling of deciduas from pre-eclamptic and normotensive pregnancies. Homo sapiens

Genome-wide analysis of decidual transcriptome in pre-eclampsia compared with normotensive controls to find differentially expressed genes/pathways. Preeclampsia (PE) is a common and serious pregnancy hypertensive disorder with a strong genetic component. The study aims were to use genome-wide analysis of decidual transcriptome in pre-eclampsia compared with normotensive controls to identify differentially expressed biological pathways, and to determine common pathways between the transcriptome and previously identified maternal susceptibility genes. Overall design: Total RNA from decidua basalis obtained from pre-eclamptic and normotensive control patients at Caesarean section