Supplementary Table S15 from A Functional Survey of the Regulatory Landscape of Estrogen Receptor–Positive Breast Cancer Evolution

Supplementary Table S15: Results of the enrichment analyses looking for binding sites of specific TFs accumulating a greater or a smaller number of genetic variants than expected by change. For each TF and category (mutations significantly increasing or decreasing affinity) the observed and expected fraction of mutations overlapping the TF-bound sites are indicated, along with the difference between these two fractions, and the p-value of the corresponding χ2 test. Considering each TF and the mutations affecting the affinity to its target sites either positively or negatively (based on the p-value of the test) TFs could be either classified as showing significantly more or less mutations than expected, or not significant (ns).