Synthesis of an Analogue of the Marine Polypropionate Tridachiahydropyrone

A novel approach to the formation of the unusual pyrone-containing ring systems as found in polypropionate metabolites from the Tridachia
family of marine molluscs has been developed. This approach includes an intramolecular cyclization of a β-keto acid onto a cyclohexenone
ring to afford a fused, bicyclic pyrone.