Expression eQTL underlying Asthma GWAS hits.

*Beneath the SNP ID in column 1, the reference allele and risk allele are shown (e.g. for rs7216389, C is the reference allele and T the risk allele).**Moffatt et al. [9] reported that rs3859192 in the 17q region was associated with asthma (P = 1.12×10−12). SNP rs3859192 was the most significant eSNP at this locus – strongly associated with GSDMA levels (P = 3.55×10−151) but weakly associated with GSDMB levels (P = 3.86×10−5).***Moffatt et al. [9] reported that SNPs at the IL1RL1 locus were associated with asthma and the GWAS peak was located at rs3771166. The latter SNP was not a strong lung eSNP (failed to pass 10% FDR). Another SNP at the IL1RL1 locus, rs13431828, was strongly associated with asthma (Moffatt et al. [9], P = 1×10−10) and IL1RL1 expression level (P = 7.48×10−8).