Diheteromeric GluN1/GluN2A (delM653) in nanodisc complex with glycine, glutamate, and GNE-4123, open conformation, C2 symmetry

Diheteromeric GluN1/GluN2A (delM653) in nanodisc complex with glycine, glutamate, and GNE-4123, open conformation, C2 symmetry Descriptor: 4-cyclohexyl-N-[(8R)-2-cyclopropyl-7-hydroxy-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]benzene-1-sulfonamide, CHOLESTEROL HEMISUCCINATE, DODECANE, ... Authors: Jalali-Yazdi, F, Kim, J, Gouaux, E. Deposit date: 2024-06-10 Release date: 2025-09-24 Last modified: 2026-02-04 Method: ELECTRON MICROSCOPY (3.22 Å) Cite: Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements. Sci Adv, 11, 2025

异源二聚体GluN1/GluN2A（delM653）与甘氨酸、谷氨酸及GNE-4123结合的纳米圆盘复合物，呈开放构象，具有C2对称性。配体描述符：4-环己基-N-[(8R)-2-环丙基-7-羟基-5-甲基[1,2,4]三唑并[1,5-a]嘧啶-6-基]苯-1-磺酰胺、胆固醇半琥珀酸酯、十二烷等。作者：Jalali-Yazdi F、Kim J、Gouaux E。存档日期：2024-06-10；发布日期：2025-09-24；最后修改日期：2026-02-04。实验方法：电子显微镜（分辨率3.22 Å）。引用文献：《NMDA受体激活的冷冻电镜快照揭示序列重排机制》，Science Advances（Sci Adv），第11卷，2025年。