HSPA1A can alleviate CFA-induced inflammatory pain by modulating macrophages

Current clinical approaches for managing inflammatory pain are frequently accompanied by adverse effects, significantly compromising patients' quality of life. This study investigates the analgesic potential of murine HSPA1A protein administration in alleviating Complete Freund's Adjuvant (CFA)-induced inflammatory pain. Findings indicate that HSPA1A mitigates CFA-induced mechanical allodynia positively correlated with macrophage abundance. Transcriptomic RNA sequencing suggests involvement of inflammation-associated pathways in plantar tissues after HSPA1A injection. Overall design: This study investigates the analgesic potential of murine HSPA1A protein administration in alleviating Complete Freund's Adjuvant (CFA)-induced inflammatory pain.Plantar tissues from HSPA1A-treated and control mice were collected.