Structure of hPNMT with inhibitor 3-Hydroxymethyl-7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy

Structure of hPNMT with inhibitor 3-Hydroxymethyl-7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy Descriptor: (3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE Authors: Drinkwater, N, Gee, C.L, Martin, J.L. Deposit date: 2006-03-02 Release date: 2006-09-12 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Comparison of the Binding of 3-Fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with Their Isosteric Sulfonamides to the Active Site of Phenylethanolamine N-Methyltransferase J.Med.Chem., 49, 2006

结合抑制剂3-羟甲基-7-(N-4-氯苯氨基磺酰基)-1,2,3,4-四氢异喹啉（3-Hydroxymethyl-7-(N-4-chlorophenylaminosulfonyl)-THIQ）与S-腺苷-L-高半胱氨酸（S-ADENOSYL-L-HOMOCYSTEINE, AdoHcy）的人苯乙醇胺N-甲基转移酶（human Phenylethanolamine N-methyltransferase, hPNMT）的晶体结构
Descriptor: (3R)-N-(4-氯苯基)-3-(羟甲基)-1,2,3,4-四氢异喹啉-7-磺酰胺、苯乙醇胺N-甲基转移酶（Phenylethanolamine N-methyltransferase）、S-腺苷-L-高半胱氨酸（S-ADENOSYL-L-HOMOCYSTEINE）
Authors: Drinkwater N、Gee C.L、Martin J.L
Deposit date: 2006年3月2日
Release date: 2006年9月12日
Last modified: 2024年10月23日
Method: X射线衍射（分辨率2.15埃）
Cite: 《3-氟甲基-7-磺酰基-1,2,3,4-四氢异喹啉及其同电子等排体磺酰胺与苯乙醇胺N-甲基转移酶活性位点的结合特性比较》，《药物化学杂志》（J.Med.Chem.），第49卷，2006年