Histone H3.3 is required for endogenous retroviral element silencing and genome stability

ChEBI2015-05-05 更新2026-07-21 收录

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基因组稳定性

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-59189 数据链接链接失效反馈

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Histone H3.3 is required for endogenous retroviral element silencing and genome stability

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2015-05-05

Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation

组蛋白修饰与肿瘤发生

表观遗传调控

In this study, our results support a functional divergence between H3K36me2 and H3K36me3 and their non-redundant roles in H3K36M-driven oncogenesis Overall design: 17 ChIP-seq samples, 3 RNA-seq sampl

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Identification of introduced and stably inherited DNA methylation variants in soybean associated with soybean cyst nematode parasitism [RNA-seq]

大豆抗线虫研究

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Methylome changes mediated by the soybean cyst nematode resistance gene GmSHMT08 Overall design: Examining the changes in the transcriptome of two nearly isogenic lines (TN09-16 and TN09-29) under soy

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DNMT3A Reads and Connects Histone H3K36me2 to DNA methylation [RNA-seq]

表观遗传调控

甲基化反应机制

DNA methylation at the 5-position of cytosine (5mC) is a crucial epigenetic mark in regulating biological processes including gene silencing, gene imprinting, and X chromosome inactivation. It has lon

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Epigenetic basis for monocyte dysfunction in acute-on-chronic liver failure and alcoholic hepatitis [RNA-seq]

肝病相关单核细胞功能障碍

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BACKGROUND/ AIMS: Severe forms of alcoholic liver disease are associated with increased susceptibility to infections largely due to immune dysfunction. In this study, we analyze the phenotypic, molecu

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Transcriptional Dynamics of Skeletal Muscle in Obesity (PRJCA023478)

肥胖相关转录组学

表观遗传调控

Skeletal muscle is a metabolically active organ, but it remains largely unexplored in obesity. Here, we used diet-induced mice as obesity model to investigate the effect of obesity on muscle transcrip

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Histone H3.3 is required for endogenous retroviral element silencing and genome stability

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