Gut microbiota from children Targeted Locus (Loci)

Inflammatory bowel disease (IBD) comprises two main subtypes, Crohn’s disease (CD) and ulcerative colitis (UC). While previous studies have highlighted the importance of the host innate immune response to bacteria and shown us that multiple pathways are involved in the pathogenesis of IBD, we remain surprisingly ignorant on the root cause(s) and pathogenesis of IBD. In this study, we recruited newly diagnosed children with IBD prior to the initiation of treatment and employed a novel sampling approach to collect and characterize the microbiota at the intestinal mucosal interface. The main objective of this study is to characterize the contribution of the gut microbiota to pediatric inflammatory bowel disease.