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X-CGD iPS cells before and after genome editing by designer nucleases

ChEBI2015-02-28 更新2026-07-21 收录

X-CGD疾病建模

iPSC基因编辑

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-66337 数据链接链接失效反馈

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资源简介：

X-CGD iPS cells before and after genome editing by designer nucleases

应用场景：

创建时间：

2015-02-28

CRISPR脱靶分析

iPSC基因编辑

Confirmation of the nuclease acivities at the On- and Off-target sites. Genomic DNA was extracted using G-DEXTM IIc genomic DNA extraction kit (iNtRON Biotech) according to manufacturer’s protocols fr

NIAID Data Ecosystem50

CRISPR transduction of iPS cells

iPSC基因编辑

巨噬细胞功能

Genome engineering using CRISPR/Cas9 technology enables simple, efficient and precise genomic modifications in human cells. Conventional immortalized cell lines can be easily edited or screened using

NIAID Data Ecosystem40

Modeling Fanconi Anemia pathogenesis and therapeutics using integration-free patient iPSCs [RNA-seq]. Homo sapiens

Fanconi贫血病理机制

iPSC基因编辑

We compared the epigenetic status of the mutant and disease-free iPSCs at the whole genome level. Whole epigenome profiling based on trimethylated H3K4 (H3K4me3) showed concordant epigenetic remodelin

NIAID Data Ecosystem20

Additional file 9 of Clinical exome analysis and targeted gene repair of the c.1354dupT variant in iPSC lines from patients with PROM1-related retinopathies exhibiting diverse phenotypes

遗传性视网膜疾病基因分析

iPSC基因编辑

Supplementary file 9: Sequencing data from IRD2’ daughter.

Figshare2024-08-18 更新40

Homo sapiens Exome. Homo sapiens

WAS综合征基因校正

iPSC基因编辑

In this study, we sought to determine the requirements for targeted integration of a corrective DNA construct into the endogenous WAS locus of WAS-patient derived iPS cells. Our goal was to demonstrat

NIAID Data Ecosystem30

X-CGD iPS cells before and after genome editing by designer nucleases

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