Top 20 models with highest congruence to human AD.

Overall rank from over 500 models and ranking is based on the hypergeometric score that rewards matching in same direction (up-up and down-down) while penalizing opposite patterns. Full scoring details provided in S1 File. Each of the top models was from mice except for Flinders and bulbectomize which were from rats. Model numbers in lower case “m” are from our previous [25] and current study while upper case “M” with upper case “A” added are from a different study [18] with original numbering used. GEO Omnibus or Synapse numbers are provided. Abbreviations: E, embryonic day; KO, knockout; cKO, conditional KO; CP, caudate putamen; sCreutzfeld-Jakob, sporadic Creutzfeld-Jakob; and TBI, traumatic brain injury. References (if available) are shown under genotype.