Gene expression in the colon from IL10 KO mice. Gene expression in the colon from IL10 KO mice

That commensal bacteria can influence intestinal inflammation has been observed using other models of chronic colitis. Loss of IL-10, a major immunosuppressive cytokine, induces spontaneous colitis in mice. The incidence of spontaneous polyp formation in IL-10-deficient mice was also completely eliminated in the absence of STING We used microarrays to evaluate the inflammatory cytokine expression in the colon from IL10 KO mice and IL10/STING KO mice. Overall design: We generated the IL10KO, IL10/STINGKO mice to compare the gene expression profile in the colon from those mice.