Mutations Indentified in Protein Kinase Genes.

NOTE: The mutations are listed by gene alongside the samples in which they were found. The nucleotide numbering uses the A of the ATG translation initiation start site as nucleotide + 1, based on reference sequences provided in Supplementary Table S3.
ac., cDNA sequence; g., genomic sequence; ins, insertion; p., protein sequence; fs, frameshift mutation.
bThe insertion of the nucleotide A causes a frameshift and leads to a premature stop codon at amino acid 896.
cn.d., not determined.
dAVC, ampulla of Vater cancer; PDAC, pancreatic ductal adenocarcinoma.
eThe genetic alteration identified were cross-referenced with variant information from databases and literature (see Materials and Methods section for details).