Drd1

Enables G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gs. Involved in adenylate cyclase-activating dopamine receptor signaling pathway; modification of postsynaptic structure; and presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including central nervous system development; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendritic spine; endoplasmic reticulum; and nucleus. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in hypertension and kidney failure. Orthologous to human DRD1 (dopamine receptor D1). [provided by Alliance of Genome Resources, Nov 2024]

该基因激活G蛋白偶联受体活性和多巴胺神经递质受体活性，通过Gs蛋白实现偶联。参与腺苷酸环化酶激活的多巴胺受体信号通路；突触后结构的修饰；以及化学突触传递的突触前调节。在多个细胞组分中发挥作用，包括树突棘、内质网和细胞核。在GABA能突触、谷氨酸能突触和突触膜上活性显著。在消化系统、大脑、泌尿生殖系统、皮肤系统和感觉器官等多种结构中表达。用于研究亨廷顿病。该基因的人类同源基因与高血压和肾功能衰竭有关。与人类DRD1（多巴胺受体D1）同源。[由基因组资源联盟提供，2024年11月]