FACTOR XIA IN COMPLEX WITH THE INHIBITOR 4-[[(1~{S})-2-[(~{E})-3-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]-3,4-dihydro-1~{H}-isoquinolin-1-yl]carbonylamino]benzoic acid

FACTOR XIA IN COMPLEX WITH THE INHIBITOR 4-[[(1~{S})-2-[(~{E})-3-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]-3,4-dihydro-1~{H}-isoquinolin-1-yl]carbonylamino]benzoic acid Descriptor: 1,2-ETHANEDIOL, 4-[[(1~{S})-2-[(~{E})-3-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]-3,4-dihydro-1~{H}-isoquinolin-1-yl]carbonylamino]benzoic acid, Coagulation factor XI, ... Authors: Sheriff, S. Deposit date: 2017-08-10 Release date: 2017-11-08 Last modified: 2026-02-18 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212). J. Med. Chem., 60, 2017

与抑制剂4-[[(1S)-2-[(E)-3-[5-氯-2-(1,2,3,4-四唑-1-基)苯基]丙-2-烯酰基]-3,4-二氢-1H-异喹啉-1-基]甲酰胺基]苯甲酸结合的凝血因子XIa（Factor XIa）复合物。描述项：1,2-乙二醇、4-[[(1S)-2-[(E)-3-[5-氯-2-(1,2,3,4-四唑-1-基)苯基]丙-2-烯酰基]-3,4-二氢-1H-异喹啉-1-基]甲酰胺基]苯甲酸、凝血因子XI…… 作者：谢里夫（Sheriff, S.）。提交日期：2017-08-10，发布日期：2017-11-08，最后修改日期：2026-02-18。实验方法：X射线衍射（分辨率2.11埃）。引用文献：《非肠道给药小分子凝血因子XIa抑制剂临床候选药物（BMS-962212）的发现》，《药物化学杂志》，60卷，2017年。