Lateral Organization and Dynamics of the Realistic Plasma Membrane

Large-scale simulations of realistic crowded cell membranes can bridge the gap between the simulations and experiments. However, the compositional complexity and structural asymmetry of cell membranes continue to pose significant challenges in computational biology. Recent advances in understanding native membranes, including their composition and protein structures, enable us to construct a highly realistic model of the mammalian plasma membrane. Using this model, we explore the organization and dynamics of biological cell membranes at the molecular level. We found that the interaction preferences of protein–lipid mediate the formation of dynamic clusters of nonrandomly distributed proteins, accompanied by heterogeneous structural properties and anomalous diffusion. These evolving dynamic clusters intertwine to form a highly complex and continuously changing protein network. Our study provides significant insights into the intricate lateral dynamic organization of cell membranes.