Social responsiveness association in RASopathy top results.

The independent SNPs with social responsiveness score (SRS) association in RASopathy (random effects meta-analysis P < 1.0x10-4) are listed. The data underlying the top six candidate modifiers are graphically illustrated in S6 Fig. For each SNP, the following is listed in order of columns: SNP rsID, chromosome (CHR), position (BP, reference version hg19), minor allele frequency in the dataset (MAF), groups contributing to the RASopathy association (group with the most significant association P-value is listed first and groups with similar direction of effect are in parentheses), Cochran’s Q P-value for all four RASopathy groups, RASopathy (CFC, CS, NF1, and NS) SRS association (random effects meta-analysis) P-value, control sibling SRS P-value (linear regression), gene(s) containing or flanking SNP.