16S microbiome of WT and AD mice treated with vehicle or NR

The goal of this study was to investigate the relationship between gut microbiota and supplementation with nicotinamide riboside (NR) in a murine Alzheimers Disease (AD) model using the APP/PS1 transgenic 2xTg AD mice compared to WT mice. AD mice have lower gut microbiome diversity, with significantly different microbiota composition and enterotype. We also identified differences between female and male AD mice. After supplementation with NR for eight weeks, the decreased diversity and perturbated microbial compositions were normalized in AD mice, including the species Oscillospira, Butyricicoccus, Desulfovibrio, Bifidobacterium, Olsenella, Adlercreutzia, Bacteroides, Akkermansia, and Lactobacillus. Our results indicate an interplay between NR and host-microbiota in APP/PS1 mice, suggesting that the effect of NR on gut dysbiosis may be an important component in its therapeutic functions in AD.