Effect of BRD4 inhibition in leukemic stem cells (Microarray)
收藏NIAID Data Ecosystem2026-03-11 收录
下载链接：
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE130634
下载链接
链接失效反馈官方服务：
资源简介：
DNA Methyltransferase 3A (DNMT3A) is frequently mutated in various hematopoietic malignancies. We report that DNMT3A mutational ‘hotspot’ at Arg882 (i.e., DNMT3A-R882H) cooperates with constitutively activated RAS in transforming murine hematopoietic stem/progenitor cells (HSPCs) ex vivo and inducing acute leukemias in vivo. Mechanistically, DNMT3A-R882H induced DNA hypomethylation facilitates gene enhancer/promoter activation. In this dataset, we provided microarray data showing effect of BRD4 inhibitor I-BET151 on gene expression in leukemic stem cells transformed by DNMT3A R882H and NRAS G12D. Gene expression data were generated using RH-RAS leukemia stem cell lines (transformed by DNMT3A R882H and NRAS G12D) treated with 100 nM I-BET-151 (a Brd4-specific small-molecule inhibitor) for 24 hours.
创建时间：
2019-06-14
