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Klf4 gene disruption is linked to enhanced cellular proliferation and tumor formation

ChEBI2010-11-25 更新2026-07-21 收录

基因功能缺失

肿瘤发生机制

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-21768 数据链接链接失效反馈

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Klf4 gene disruption is linked to enhanced cellular proliferation and tumor formation

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创建时间：

2010-11-25

干细胞转录组学

基因功能缺失

SYNCRIP depletion results in HSCs losing their self renewal abilities. Next generation sequencing was conducted in SYNCRIP WT and KO HSCs to investigate the transcriptional changes that occur, and res

NIAID Data Ecosystem60

p53 amyloid formation induced cellular transformation and tumor formation in xenograft model

p53

肿瘤发生机制

p53 mutation and its subsequent loss of function along with gain of oncogenic functions is associated with cancer. However, the exact mechanism of how altered p53 acts as an oncogene is not clear yet.

NIAID Data Ecosystem50

BubR1 depletion sequencing

基因功能缺失

饥饿胁迫响应

sequencing of BubR1 deficiency flies under starvation

NIAID Data Ecosystem30

Splicing Variation Contributes to Functional Dysregulation of Genes in Acute Myeloid Leukemia

AML可变剪接

基因功能缺失

Acute Myeloid Leukemia (AML) has been associated with somatic mutations in numerous genes; however, the penetrance of these mutations is low. Here we investigate the contribution of alternative splici

NIAID Data Ecosystem60

Expression of FUS-CHOP fusion protein in immortalized/transformed human Mesenchymal Stem Cells drives mixoid liposarcoma formation

黏液样脂肪肉瘤

肿瘤发生机制

Although different sarcomas have been modeled in mice upon expression of fusion oncogenes in MSCs, sarcomagenesis has not been successfully modeled in human MSCs (hMSCs). We report that FUS-CHOP, a ha

NIAID Data Ecosystem40

Klf4 gene disruption is linked to enhanced cellular proliferation and tumor formation

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