Extracellular spinal recordings: spontaneous activity and fictive locomotion

<em><strong>In vitro</strong></em><strong> extracellular recording dataset of spontaneous activity in normal artificial cerebrospinal fluid (aCSF) and drug-induced fictive locomotion associated with </strong><em><strong>Pocratsky et al 2023, Science Translational Medicine</strong></em> <br> <em><strong>ENG_spontAct_aCSF.xlsx: </strong></em>raw and analysed data from extracellular recordings from lumbar spinal ventral roots of postnatal spinal cords (postnataly day 3-5). Data reflects spontaneous activity observed when cords were perfused with artifical cerebrospinal fluid (aCSF). Groups: Littermate control and spinal Tor1a d-cko mice that develop early onset generalised torsional dystonia <br> <em><strong>ENG_fictiveLocomotion.xlsx:</strong></em> raw and analysed data from extracellular recordings from lumbar spinal ventral roots of postnatal spinal cords (postnatal day 1-5). Data reflects stable rhythmic bursting activity observed when cords were perfused with aCSF mixed with a cocktail of NMDA, 5-HT, and dopamine (for p3-p5 recordings, only). <br> Full methodological details can be found with publication <br> <br>