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PPP2R2D suppresses interleukin-2 production and regulatory T cell function

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NIAID Data Ecosystem2026-03-12 收录
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Upon ATAC-seq, we found that lack of PPP2R2D expression in Tconv cells boosts chromatin opening of a large number of genes, while in Treg cells chromatin remodeling is limited. These findings demonstrate that PPP2R2D is more important in the direct regulation of Tconv cell function (IL-2 production) rather than Treg cell function. Overall design: Examination of chromatin accessibility in 2 cell types

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2020-10-27
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