LIVER DEVELOPMENT IS RESTORED BY BLASTOCYST COMPLEMENTATION OF HHEX KNOCKOUT IN MICE AND PIGS

This work demonstrates that loss of liver development in the HHEX KO can be rescued via blastocyst complementation in both mice and pigs. This complementation strategy is the first step towards generating interspecies chimeras for the goal of producing human liver cells, tissues, and potentially complete organs for clinical transplantation.