Additional file 4 of Novel pathological predictive factors for extranodal extension in oral squamous cell carcinoma: a retrospective cohort study based on tumor budding, desmoplastic reaction, tumor-infiltrating lymphocytes, and depth of invasion

Additional file 4. Clinicopathological status of 83 biopsy specimens. The clinicopathological features were evaluated as follows; Sex (0: female; 1: male); cDOI 5 mm (0: ≤5 mm; 1:<5 mm); cDOI 10 mm (0: ≤10 mm; 1: DOI>10 mm); Metastasis (0: absence; 1: presence); Number of lymph node metastasis (0: n=0; 1: n=1; 2: n ≥2); Pattern of invasion (1: pattern of 1 and 2; 2: pattern of 3 and 4); LyV (0: absence; 1: presence); pT (0: pT1, 2; 1: pT3, 4); pN (0: no LN metastasis; 1: pN1; 2: pN2, and 3); ENE (0: absence; 1: presence); DR (0: DR-M; 1: DR-I); TB (0: TB-L; 1: TB-H); TILs (0: TILs-L; 1: TILs-H); TB-H/cDOI >10 mm (0: no; 1: yes); DR-I/TILs-L (0: no; 1: yes); DR-I/TILs-L/cDOI >10 mm (0: no; 1: yes).cDOI, clinical depth of invasion; pT, pathological T; pN, pathological N; ENE, extranodal extension; DR, desmoplastic reaction; TB, tumor budding; TILs, tumor-infiltrating lymphocytes; TB-H, high tumor budding; DR-I, immature desmoplastic reaction; TILs-L, low-grade tumor-infiltrating lymphocytes.