Robustness-Annotated Temporal Graph with Temporal Consistency Score (RATG-TCS): A Reporting Protocol for Directional Biomarker Evidence in Chronic Kidney Disease

Reproducibility archive for the manuscript "RATG-TCS: A Reporting Protocol for Directional Biomarker Evidence in Chronic Kidney Disease" (Tanigawa et al., BMC Medical Research Methodology, 2026). Contains: (1) all analysis code implementing the reporting protocol (partial correlation networks, multi-lag cross-lagged partial correlation with two covariate-control specifications, MICE m=20 with Rubin's rules pooling and cluster bootstrap, within-patient fixed-effects primary + between-patient-inclusive sensitivity, temporal consistency scoring under two windowing schemes, ground-truth simulation validation across 11 data-generating processes, random-intercept + random-slope mixed-model sensitivity, MI-boot sensitivity, linearity diagnostic); (2) aggregate result CSVs at pair × lag × method resolution or coarser (no individual patient records); and (3) a verification harness with 201 automated cross-checks of every numerical claim in the manuscript against source CSVs. A pre-deposit safety script (verify_no_patient_data.py) is included to confirm the archive contains no patient-identifying data. Restricted access during peer review; open access at publication.