Microglia suppress Ascl1-induced retinal regeneration in mice.
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
The innate immune system plays key roles in tissue regeneration. For example, microglia promote neurogenesis in Müller glia in birds and fish after injury. Although mammalian retina does not normally regenerate, neurogenesis can be induced in mouse Müller glia by Ascl1, a proneural transcription factor. We show that in mice, microglia inhibit the Ascl1-mediated retinal regeneration, suggesting the innate immune system limits the regenerative response to injury.
提供机构：
UNIVERSITY OF WASHINGTON
创建时间：
2022-02-20
