Neutrophil Extracellular Traps Mediate Acute Liver Failure in Regulation of miR-223/neutrophil Elastase Signaling in Mice. Neutrophil Extracellular Traps Mediate Acute Liver Failure in Regulation of miR-223/neutrophil Elastase Signaling in Mice

Marked enhancement of neutrophil infiltration of the liver is a hallmark of acute liver failure (ALF), a severe life-threatening disease with varying etiologies. However, the mechanisms underlying the regulation of neutrophil entry into the liver and their pathophysiological role during ALF development remain poorly characterized. Overall design: Comparative gene expression profiling analysis of RNA-seq data using bone marrow cells from miR-223 KO and WT control mice