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Transcriptional changes and RNA expression profiles during ischemia-induced DRP1-mediated macrophage reprogramming

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE280186
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To reveal the molecular mechanisms underlying DRP1-mediated macrophage reprogramming during hypoxia serum starvation (HSS) an in vitro ischemia model, we performed bulk RNA-seq analysis on mouse bone marrow derived macrophages (BMDM) upon HSS-induced DRP1 mediated macrophage reprogramming. Transcriptomic (total RNA) expression profiles of wildtype (WT) and DRP1 Knock-out (DRP1-KO) BMDM after 8 h of HSS ( in vitro ischemia) stimulation were compared by RNA-seq.
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2025-02-12
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