BIOGRID CURATED DATA FOR NCR1 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for NCR1 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: Vacuolar membrane protein; transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases (LCB), similar to the accumulation of high amounts of lipids observed in patients with Neimann-Pick C, a disease caused by loss-of-function mutations in NPC1, the functional ortholog of Ncr1p

蛋白质-蛋白质、遗传和化学相互作用数据集，针对酵母菌（Saccharomyces cerevisiae S288c）中的NCR1基因，由BioGRID（https://thebiogrid.org）整理；定义：溶酶体膜蛋白；通过生物合成溶酶体蛋白分选途径进行转运，参与鞘脂代谢；缺乏Ncr1p蛋白的细胞表现出高水平的长链碱（LCB），类似于在Neimann-Pick C病患者中观察到的脂质大量积累，该疾病由NPC1功能同源蛋白Ncr1p的失活突变引起。