Tet2-mediated epigenetic modifications during aging of hematopoietic stem and progenitor cells
收藏NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE157592
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资源简介：
we compared self-renewal and lineage specification of WT and Tet2-deficient HSPCs during ageing and demonstrated that Tet2 ablation alters age-dependent HSC functional decline, revealing a disparate ageing process in the Tet2-deficient haemopoietic system. We collected hematopoietic progenitor and stem cells (HSPCs) from young and aged WT/ Tet2KO mice for scRNA-seq analysis. CD45.2+Lin-ckit+Sca-1+ cells harvested from bone marrow transplanted mice (using hematopoietic progenitor and stem cells from young and aged WT/ Tet2KO mice as donors) were collected from SMART-RNA seq
创建时间：
2023-09-10
