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Silver-Catalyzed Diastereo- and Enantioselective Michael Addition and 1,3-Dipolar Cycloaddition Reactions of Imino Esters to 3‑Methyl-4-nitro-5-styrylisoxazoles

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https://figshare.com/articles/dataset/Silver-Catalyzed_Diastereo-_and_Enantioselective_Michael_Addition_and_1_3-Dipolar_Cycloaddition_Reactions_of_Imino_Esters_to_3_Methyl-4-nitro-5-styrylisoxazoles/7291754
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The AgOAc/ThioClickFerrophos complex catalyzed conjugate additions and 1,3-dipolar cycloadditions of 3-methyl-4-nitro-5-styrylisoxazoles with 1-pyrroline-5-carboxylates and glycine imino esters to give the corresponding Michael adducts and cycloadducts, respectively, in good yields with excellent diastereo- and enantioselectivities. These reactions can provide pyrroline- or pyrrolidine-containing isoxazole hybrid molecules that have potential biological and pharmaceutical activities.
创建时间:
2018-11-02
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