<b>Raw data of Moderate to severe chronic arteriolar lesions is an independent risk factor for adverse renal outcomes in IgA nephropathy</b>

The impact of chronic arteriolar lesions on the prognosis of IgA nephropathy remains controversial. This data aims to explore the value of chronic arteriolar lesions of varying degrees in predicting the prognosis of IgA nephropathy patients and analyze the associated risk factors that contribute to the formation. A total of 574 cases were included in this study. According to the degree of chronic arteriolar lesions, the patients were divided into four groups: no lesion group, mild lesion group, moderate lesion group, and severe lesion group.Statistical analysis was performed using SPSS 26.0 software. Continuous variables were expressed as mean ± standard deviation for normally distributed variables or median and interquartile range for non-normally distributed variables. Comparisons between groups utilized either independent samples t-test or Mann-Whitney U test for two-group comparisons and a one-way analysis of variance (ANOVA) or the Kruskal-Wallis H test for three-group comparisons, with the Bonferroni test applied for multiple comparisons. Categorical variables were presented as frequency and percentages and analyzed using the χ2 test, Fisher's exact test, or Kruskal-Wallis test (if applicable). The cumulative incidence of reaching the composite endpoint was assessed using the Kaplan–Meier method and compared using the log-rank test. Univariate and multivariate Cox regression analyses were used to evaluate factors significantly associated with composite endpoints. Multivariable regression analysis was conducted for significant univariate factors, presenting the results as adjusted hazard ratios (aHR) with a 95% confidence interval (CI). Receiver operating characteristic curves (ROC) were plotted, and the area under the curve (AUC) was calculated. The optimal cut-off value was determined based on the maximum Youden index. Logistic regression analysis was utilized to identify the associated risk factors for moderate to severe chronic arteriolar lesions. Missing data were addressed using multiple imputation techniques. Continuous variables were imputed through linear regression models, while categorical variables were imputed using logistic regression models. The imputation process was repeated five times to ensure robustness.A significance level of α=0.05 was used, with P&lt;0.05 considered statistically significant. Analysis was conducted using anonymized data accessed on June 08, 2023, ensuring that only de-identified data were utilized for the study.This study has been approved by the Ethics Committee of Guangdong Provincial Hospital of Traditional Chinese Medicine (Approval No. YE2022-181-01), which is in line with the ethical principles of clinical research as well as the Declaration of Helsinki and International Ethical Guidelines for Research Involving Human Health, among other documents.