CommonMind Consortium Knowledge Portal

we present a public resource of functional genomic data from the dorsolateral prefrontal cortex (DLPFC; Brodmann areas 9 and 46) of 986 individuals from 4 separate brain banks, including 353 diagnosed with schizophrenia and 120 with bipolar disorder. The genomic data include RNA-seq and SNP genotypes on 980 individuals, and ATAC-seq on 269 individuals, of which 264 are a subset of individuals with RNA-seq. We have performed extensive preprocessing and quality control on these data so that the research community can take advantage of this public resource available on the Synapse platform at http://CommonMind.org.

本研究公开了一套来自4个独立脑库的986名个体的背外侧前额叶皮层（dorsolateral prefrontal cortex, DLPFC；布罗德曼分区9区与46区）功能基因组学公共资源，其中353名被确诊为精神分裂症，120名被确诊为双相情感障碍。该数据集包含980名个体的RNA测序（RNA-seq）与单核苷酸多态性（single nucleotide polymorphism, SNP）基因型数据，以及269名个体的转座酶可及性测序（ATAC-seq）数据，其中264名个体为拥有RNA-seq数据的子集样本。本团队已对上述数据开展了全面的预处理与质量控制工作，以便科研界可利用该公开资源，相关数据可通过Synapse平台的http://CommonMind.org获取。

搜集汇总

背景与挑战

背景概述

该数据集是一个公共功能基因组资源，包含来自986个个体前额叶皮层的RNA-seq、SNP基因型和ATAC-seq数据，其中部分样本涉及精神分裂症和双相情感障碍诊断。数据经过预处理和质量控制，可通过Synapse平台访问。