Figure S1 - β Subunit M2–M3 Loop Conformational Changes Are Uncoupled from α1 β Glycine Receptor Channel Gating: Implications for Human Hereditary Hyperekplexia

Amino acid sequence alignment between the human GlyR α1 and β subunits. The joining sites for chimera construction are highlighted in blue. The K24′, V25′ and Y27′ residues, where hyperekplexia-mimicking mutations were introduced, are highlighted in red. The α1R19′ and βA19′ residues, where the Cys mutation was introduced for VCF experiment, are highlighted in green. (DOC)