Effect of aerobic exercise and low carbohydrate diet on pre-diabetic with non-alcoholic fatty liver disease

In the present study, we analyzed the composition and metabolic pathways of the gut microbiota, constructed a co-occurrence network at the population level, and developed personalized gut microbial networks. This individual network enabled us to identify the microbial signature and interaction of taxa at a personal resolution, and to further differentiate responders from low/non-responders after intervention. Taken together, our study with relatively long-term intervention provides both statistical and sample-specific network insights into the complex gut microbial ecosystem in patients with non-alcoholic fatty liver disease (NAFLD) and glucose metabolism impairment.