Supplementary Material for: Improvement in Dry Age-Related Macular Degeneration with Photobiomodulation

Introduction: This case report describes a finding of dramatic improvement in drusen volume and visual acuity in a 73-year-old patient diagnosed with dry age-related macular degeneration (AMD) undergoing daily home photobiomodulation alongside AREDS-2 supplements.

Presentation: This is a retrospective review of a case presentation from 2023-2024. After 8 months of continuous home photobiomodulation, the patient’s visual acuity improved from 20/30 to 20/20 in the left eye while the right eye stabilized at 20/25. The outer retina was preserved without signs of geographic atrophy, with a robust reduction in total number and volume of drusen in both eyes, left greater than right, as shown with optical coherence tomography (OCT) macular cross-sectional scans.

Conclusions: These findings support that photobiomodulation has the potential to improve the management of dry AMD and the overall quality of life, consistent with phase III clinical trials. Future studies are warranted to further establish optimized protocols for broader clinical implementation.