Furnishing Amine-Functionalized Metal–Organic Frameworks with the β‑Amidoketone Group by Postsynthetic Modification

Postsynthetic modification (PSM) of amino-functionalized metal–organic frameworks (MOFs) to those bearing pendant β-amidoketone arms using diketene is herein reported. Three unique MOF families demonstrate the scope of this transformation, which both is atom-economical and yields high conversions. In each case, the crystallinity was retained, and instances of exceptional solid-state ordering were observed in the PSM products, which has allowed detailed crystallographic characterization in multiple instances.