Enantioselective Conjugate Addition of 2‑Acetyl Azaarenes to β,β‑Disubstituted Nitroalkene for the Construction of All-Carbon Quaternary Stereocenters

The first highly enantioselective
conjugate addition of 2-acetyl
azaarenes to α-substituted-β-nitro­acrylates was
successfully realized under mild conditions by a Ni­(II)-bisoxa­zoline
complex, providing the desired adducts bearing an all-carbon quaternary
stereocenter in high yield with excellent enantioselectivity. The
products obtained in this system could be readily converted into optically
active β2,2-amino esters, succinates, lactones, and
lactams.