Data from: The majority of transcripts in the squid nervous system are extensively recoded by A-to-I RNA editing

RNA editing by adenosine deamination alters genetic information from the
genomic blueprint. When it recodes mRNAs, it gives organisms the option to
express diverse, functionally distinct, protein isoforms. All eumetazoans,
from cnidarians to humans, express RNA editing enzymes. However,
transcriptome-wide screens have only uncovered about 25 transcripts
harboring conserved recoding RNA editing sites in mammals and several
hundred recoding sites in Drosophila. These studies on few established
models have led to the general assumption that recoding by RNA editing is
extremely rare. Here we employ a novel bioinformatic approach with
extensive validation to show that the squid Doryteuthis pealeii recodes
proteins by RNA editing to an unprecedented extent. We identify 57,108
recoding sites in the nervous system, affecting the majority of the
proteins studied. Recoding is tissue-dependent, and enriched in genes with
neuronal and cytoskeletal functions, suggesting it plays an important role
in brain physiology.