Kwang2003 - The influence of RKIP on the ERK signaling pathway

Kwang2003 - The influence of RKIP on the ERK
signaling pathway

This model is described in the article:

Mathematical Modeling of the
Influence of RKIP on the ERK Signaling Pathway

Kwang-Hyun Cho, Sung-Young Shin,
Hyun-Woo Kim, Olaf Wolkenhauer, Brian McFerran and Walter
Kolch
Computational Methods in Systems
Biology: First International Workshop, CMSB 2003 Rovereto, Italy,
February 24â??26, 2003 Proceedings
Abstract:

This paper investigates the influence of the Raf Kinase
Inhibitor Pro- tein (RKIP) on the Extracellular signal
Regulated Kinase (ERK) signaling pathway through mathematical
modeling and simulation. Using nonlinear ordi- nary
differential equations to represent biochemical reactions in
the pathway, we suggest a technique for parameter estimation,
utilizing time series data of proteins involved in the
signaling pathway. The mathematical model allows the simulation
the sensitivity of the ERK pathway to variations of initial
RKIP and ERK-PP (phosphorylated ERK) concentrations along with
time. Throughout the simulation study, we can qualitatively
validate the proposed mathematical model compared with
experimental results.

This model is hosted on
BioModels Database
and identified by:
BIOMD0000000647.
To cite BioModels Database, please use:
Chelliah V et al. BioModels: ten-year
anniversary. Nucl. Acids Res. 2015, 43(Database
issue):D542-8.

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