Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer

Protein Data Bank Japan2023-09-06 更新2026-03-21 收录

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Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer Descriptor: 5-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)pyridin-2-amine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Authors: Murray, J.M, Wiesmann, C. Deposit date: 2009-12-10 Release date: 2010-02-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer. J.Med.Chem., 53, 2010

用于癌症治疗的强效、选择性且可口服的泛磷脂酰肌醇3-激酶（Pan-PI3-Kinase）及双泛PI3K/哺乳动物雷帕霉素靶蛋白（mTOR）抑制剂的（噻吩并嘧啶-2-基）氨基嘧啶类化合物的发现描述符：5-(6-{[4-(甲磺酰基)哌嗪-1-基]甲基}-4-吗啉代噻吩并[3,2-d]嘧啶-2-基)吡啶-2-胺、磷脂酰肌醇-4,5-二磷酸3-激酶催化亚基γ亚型作者：Murray, J.M.、Wiesmann, C. 存入日期：2009-12-10 发布日期：2010-02-16 最后修改日期：2023-09-06 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.9埃（Å）引用文献：用于癌症治疗的强效、选择性且可口服的泛PI3K及双泛PI3K/mTOR抑制剂的（噻吩并嘧啶-2-基）氨基嘧啶类化合物的发现，《药物化学杂志》（J.Med.Chem.），第53卷，2010年

创建时间：

2009-12-10