Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 6-((2-((4-cyanophenyl)amino)pyrimidin-4-yl)amino)-5,7-dimethylindolizine-2-carbonitrile (JLJ604)
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Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 6-((2-((4-cyanophenyl)amino)pyrimidin-4-yl)amino)-5,7-dimethylindolizine-2-carbonitrile (JLJ604) Descriptor: (4R)-6-{[2-(4-cyanoanilino)pyrimidin-4-yl]amino}-5,7-dimethylindolizine-2-carbonitrile, 1,4-DIAMINOBUTANE, MAGNESIUM ION, ... Authors: Frey, K.M, Anderson, K.S. Deposit date: 2021-10-28 Release date: 2022-03-16 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.368 Å) Cite: Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase. Front Mol Biosci, 9, 2022
结合6-((2-((4-氰基苯基)氨基)嘧啶-4-基)氨基)-5,7-二甲基吲哚嗪-2-甲腈（JLJ604）的HIV-1逆转录酶（HIV-1 Reverse Transcriptase）晶体结构 描述符：(4R)-6-{[2-(4-氰基苯胺基)嘧啶-4-基]氨基}-5,7-二甲基吲哚嗪-2-甲腈、1,4-二氨基丁烷、镁离子等 作者：Frey, K.M.、Anderson, K.S. 沉积日期：2021-10-28 发布日期：2022-03-16 最后修改日期：2023-10-18 实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.368 Å） 引用文献：《新型计算机设计非核苷类抑制剂的结构研究与构效关系及其与HIV-1逆转录酶的相互作用》，《Frontiers in Molecular Biosciences（Front Mol Biosci）》，第9卷，2022年
