Enriched KEGG Pathways for the lists of differentially expressed transcripts in spleen leukocytes from 2 week and 4 week old NOD mice compared to two control strains.

One-way ANOVA (p<0.05, Benjamini-Hochberg) of mRNA expression data followed by hierarchical clustering identified 187 and 327 genes whose expression was altered in spleen leukocytes from NOD mice compared to two control strains (NON and C57BL/6) at 2 weeks and 4 weeks, respectively. The lists of differentially expressed genes were analyzed in WebGestalt (http://bioinfo.vanderbilt.edu/webgestalt) for enriched KEGG pathways using the hypergeometric test (p<0.01, Benjamini-Hochberg); dashes (-) indicate that the corresponding categories were not significantly enriched at the respective ages. Pathways represented by ≥2 genes are shown. Bold text indicates categories that were common to both age groups; ECM, extracellular membrane.