Vonoprazan pharmacokinetics and effects on gastric pH following administration to fed and fasted horses

This dataset supports research characterizing the pharmacokinetics of vonoprazan and investigating its effects on gastric pH in horses. The data set includes pharmacokinetic parameters for individual horses generated using non-compartmental pharmacokinetic analysis and the commercially available software program Phoenix WinNonlin (Certara, Princeton, NJ). Pharmacokinetic parameters generated from the pilot study (2 horses/group), assessing the effects of food on drug behavior (0.5 and 1 mg/kg oral doses), and a “full” study (n=6 horses) assessing the effects of a 1 mg/kg oral dose administered with food are included. A second data set includes gastric pH measurements as part of the “full” study (n=6 horses), both before and after vonoprazan administration (1 mg/kg oral dose). Measurements were collected via an engineered probe that was used to continuously measure intragastric pH for 12 hours before and 24 hours after each treatment. Sandhill Scientific software (Milwaukee, WI, USA) was..., The study was conducted as a randomised four‐way balanced crossover study. Six horses received vonoprazan (0.5 and 1 mg/kg), omeprazole (4 mg/kg), and water (60 mL). Blood samples were collected prior to and up to 72 h post‐administration. Plasma vonoprazan concentrations were measured using liquid chromatography–tandem mass spectrometry, and non‐compartmental and compartmental pharmacokinetic analyses were performed. Intragastric pH was continuously recorded 12 h before and 24 h after each treatment. The percentage of time pH remained above 4 was compared among treatments.
, # Vonoprazan pharmacokinetics and effects on gastric pH following administration to fed and fasted horses

Dataset DOI: [10.5061/dryad.8w9ghx41m](https://doi.org/10.5061/dryad.8w9ghx41m)

## Description of the data and file structure

The first data set lists individual animal pharmacokinetic parameters for both the pilot study (fed vs fasted) and the full study (0.5 and 1 mg/kg doses). Parameters were generated using non-compartmental analysis (NCA) and the software program Phoenix WinNonlin (Certara, Princeton, NJ).

The second data set lists % of the time that pH was above and below 4 for individual animals. Dose groups include 0.5 and 1 mg/kg, omeprazole (positive control), and water (negative control).

### Files and variables

#### File: Pharmacokinetic_Parameters.xlsx

**Description:** Pharmacokinetic parameters for the pilot and full study as generated by Phoenix WinNonlin software and non-compartmental analysis (NCA)

##### Variables

* Horse
* Dose
* Lambdaz: terminal slope
* ...,